论文对绝大多数的朋友们来说是必不可少的，为了让朋友们都能顺利的编写出所需的论文，论文频道小编专门编辑了“正交设计优选解酒肝康颗粒的提取工艺”，希望可以助朋友们一臂之力!

Abstract：Objective To study the extraction process of Jiejiu Gankang granules by orthogonal test. Methods With the ethanol extraction rates of the medical materials like ginseng, radix salviae miltiorrhizae, the water extraction rates of the medical materials like hawthorn, and Tanshinone ⅡA as the parameters, the extract conditions of Jiejiu Gankang granules was optimized by orthogonal design. Results The optimal preparation process was as follows：the mixture of medical materials like ginseng and Schisandra chinensis was refluxed twice with total 10 times of 70% alcohol, 2.0 hours for each time, and then the mixture of medical materials like hawthorn extracted twice with total 10 times of boiling water, 2.0 hours for each time. Conclusion The optimal preparation process is reasonable and with high extraction rate of active components.

Key words：Jiejiu Gankang granules;preparation procedure;orthogonal test;Tanshinone

解酒肝康颗粒主要由人参、丹参、山楂等组成,具有疏肝理脾、解酒祛湿、祛瘀行滞的功效,临床用于治疗酒精性脂肪肝。根据本制剂药物组成、功效及理化性质,笔者对本制剂进行了提取工艺正交设计的优选研究。

1 仪器与试药

高效液相色谱仪(美国Waters2695),检测器为Waters2996二级管阵列检测器,泵Waters2695四元梯度泵,控制器为Waters2695,数据处理器为Waters M32工作站。色谱柱为Diamonsil C18柱(250 mm×4.6 mm,5 μm,DIKMA科技)。水为超纯水(Millipore公司纯水器),乙腈、甲醇为色谱纯,其它所用试剂均为分析纯。丹参酮ⅡA对照品购于中国药品生物制品检定所,供含量测定用,批号110875-200507。

2 方法与结果

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